Bioinformatics & Genomic Sequencing

Public health, biosecurity and industry communities are both driving and benefitting from advancements in genomics research with next-generation sequencing (NGS) technology. Whole genome sequencing is now ubiquitous and produces terabytes of data for processing, interpretation and – potentially – action. Signature Science’s bioinformatics (genome and transcriptome) expertise, genomics research (massively parallel sequencing and whole genome sequencing) and synthetic biology capabilities, together, are driving innovative solutions in this space.

Biosecurity Applications

DNA synthesis technologies are enabling rapid advancements in the field of synthetic biology, which involves the design and fabrication of novel biological components. The immense promise of DNA synthesis technology is unmistakable, but so is its potential for intentional or accidental misuse. Biosecurity professionals and genome engineers can use Signature Science’s bioinformatics workflows and tools and biocuration services to identify sequences of concern and root out potential threats.

Public Health Applications

Signature Science uses sequencing and bioinformatics workflows to study the detailed genome of pathogens, the function of the genome’s segments, and their interactions with hosts. We can detect a wider variety of pathogens and gain better understanding of pathogen characteristics such as virulence, stability and antimicrobial resistance. Signature Science is using synthetic biology techniques to establish a laboratory model of viral evolution for pandemic viruses to offer public health entities a tool to support the prediction of evolutionary pathways and phenotypes of viral threats.

A SigSci Solution
Modeling the Transmission of Highly Drug-Resistant Pathogens in Healthcare Settings
A SigSci Solution
FOCUS: Signature Science Funded Modeling Project to Forecast COVID-19 in the United States

Krista Ternus, PhD
Genomics Specialist

For more information about Bioinformatics and Genomic Sequencing