About Signature Science

We serve government and commercial clients through a wide array of technical offerings that combine scientific rigor with proven quality assurance. Our expertise enhances the credibility and defensibility of government programs that provide for National Security, Public Safety and Security, and Health Security.

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We Solve Problems Using Applied Science and Technology

Across many disciplines, our project teams are addressing some of the toughest challenges facing our local communities, our nation, and our world.

Health Security
Public Safety and Security
National Security

Join Our Team

We’re hiring

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A Compelling Work Environment and Culture

Signature Science employees benefit from a compelling work environment and corporate culture that are shaped by our pursuit of scientific innovation and service to our clients’ vital missions.

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Tackling the Toughest Scientific Problems

We bring together the brightest minds from across the scientific disciplines to apply high-quality analysis and technical skills to meet new and developing challenges. Check our current openings to see where you fit.


Here’s what’s happening at Signature Science lately.

Dr. Joe McDonough Joins Signature Science’s Managers Committee

McDonough serves as Vice President of Southwest Research Institute’s Chemistry and Chemical Engineering Division AUSTIN, TEXAS — November 16, 2023 – Signature Science, LLC is pleased to announce the election of Dr. Joe McDonough to its Managers Committee. In 2022, Dr. … MORE

Signature Science Brings Bioscience Expertise to Amentum on Newly Awarded DTRA Project to Strengthen and Maintain Partner Nation-Owned Laboratories in Africa

SigSci will develop and execute training plans and provide laboratory quality assurance support. AUSTIN, TEXAS – October 17, 2023 – Globalization fosters connection and progress across national boundaries. However, as demonstrated by health crises like the COVID-19 pandemic and 2014 Ebola … MORE

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Published in ACM Digital Library: SeqScreen-Nano: a computational platform for streaming, in-field characterization of microbial pathogens

Abstract The COVID-19 pandemic forever underscored the need for bio-surveillance platforms capable of rapidly detecting emerging pathogens. Oxford Nanopore Technology (ONT) couples long-read sequencing with in-field capability, opening the door to real-time, in-field biosurveillance. Though a promising technology, streaming assignment of … MORE

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