Published in “Frontiers in Bioengineering and Biotechnology”: Improved Understanding of Biorisk for Research Involving Microbial Modification Using Annotated Sequences of Concern

FunSoCs Biosecurity Paper Published i Frotiers inbioengineering and Biotechnology


Regulation of research on microbes that cause disease in humans has historically been focused on taxonomic lists of ‘bad bugs’. However, given our increased knowledge of these pathogens through inexpensive genome sequencing, 5 decades of research in microbial pathogenesis, and the burgeoning capacity of synthetic biologists, the limitations of this approach are apparent. With heightened scientific and public attention focused on biosafety and biosecurity, and an ongoing review by US authorities of dual-use research oversight, this article proposes the incorporation of sequences of concern (SoCs) into the biorisk management regime governing genetic engineering of pathogens. SoCs enable pathogenesis in all microbes infecting hosts that are ‘of concern’ to human civilization. Here we review the functions of SoCs (FunSoCs) and discuss how they might bring clarity to potentially problematic research outcomes involving infectious agents. We believe that annotation of SoCs with FunSoCs has the potential to improve the likelihood that dual use research of concern is recognized by both scientists and regulators before it occurs.

Read full paper here.


Gene D. Godbolda, F. Curtis Hewittb, Anthony D. Kappellb, Matthew B. Scholzb, Stacy L. Agara, Todd J. TreangencKrista L. Ternusb, Jonas B. Sandbrinkd and Gregory D. Koblentze

a Signature Science, LLC, Charlottesville, VA, United States
Signature Science, LLC, Austin, TX, United States
Department of Computer Science, Rice University, Houston, TX, United States
Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Schar School of Policy and Government, George Mason University, Arlington, VA, United States