May 12, 2026

Horizon Newsletter – May 2026

Signature Science has validated a SNP mixture deconvolution workflow for two-person DNA mixtures, a breakthrough enabling new leads from evidence previously unusable. When a sample contains DNA from two contributors, our process separates the mixture to produce a single-source SNP profile for the major contributor, making it suitable for forensic... MORE
April 28, 2026

Published in “FSI Genetics”: Advancing forensic SNP typing: Insights from an interlaboratory study of the...

Abstract: This study evaluated the ability to produce FORensic Capture Enrichment (FORCE) genotypes using amplicon-based and capture-based enrichment assays. The FORCE panel is a standardized set of single nucleotide polymorphism (SNP) markers developed for forensic applications. Twelve DNA samples were prepared and distributed to the laboratories for testing: five control... MORE
March 16, 2026

Signature Science Interviewed for RAND AI Safety Paper

March 16, 2026 • Last year, Signature Science AI Biosafety Lead Dr. Danielle LeSassier was interviewed as part of a multi-institutional study led by RAND into the state of Human Uplift Studies for informing AI Safety. As providers in this space, SigSci designs approaches to empirically test the biological and chemical... MORE
February 27, 2026

Horizon Newsletter – February 2026

We’re gearing up for another ASCLD Symposium and are excited to be part of 2026’s packed agenda! We’re hosting two plenary talks and one deep dive session. Scroll for a preview of SigSci Forensics on the agenda. Dates & Times TBA! View full Horizon Newsletter and sign up for future... MORE
February 10, 2026

New Preprint: Predicting Neutron Radiation Exposure Characteristics from an in vitro Human Skin Model Using RNA-seq

Abstract: Accurate assessment of low-dose neutron radiation exposure remains a central challenge in biodosimetry, particularly for applications requiring non-invasive sample types such as skin. Here, we characterized the transcriptional response of a three-dimensional in vitro human skin model (EpiDermFT) to neutron irradiation at doses up to 0.75 Gy, measured from pre-exposure through... MORE

Dr. Ben H. Thacker Joins Signature Science’s Managers Committee

Thacker serves as Chief Operating Officer of Southwest Research Institute. AUSTIN, TX - February 10, 2026 - Signature Science, LLC is pleased to announce the addition of Dr. Ben H. Thacker, P.E. to its Managers Committee following his appointment as Southwest Research Institute's Chief Operating Officer. Dr. Thacker brings nearly... MORE
January 5, 2026

Published in “Applied Biosafety”: Inter-tool Analysis of a NIST Dataset for Assessing Baseline Nucleic Acid Sequence...

Abstract: Introduction: Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious intent to cause harm. Thus, this technology needs to be appropriately safeguarded.... MORE
November 13, 2025

Horizon Newsletter – November 2025

Collaboration Leads to a Breakthrough in a Case That's Close to Home After over 30 years, breakthroughs in forensic science have led investigators to identify a person of interest in the 1991 murders of four young Austin-area girls; Eliza Thomas, Amy Ayers, and sisters Jennifer Harbison and Sarah Harbison. Announced... MORE
Viruses swirl into an electrified sensor
October 22, 2025

Signature Science Membership on ARPA-H BREATHE Program Team Announced

October 22, 2025 • A press release issued by The University of Virginia Biocomplexity Institute announced that the Advanced Research Projects Agency for Health (ARPA-H) has awarded a contract for up to $40 million through its Bioaerosol Risk Assessment interVention Engineering (BRAVE) program to a multidisciplinary, multi-institutional team led by Linsey... MORE