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Probabilistic Genotyping Brings Benefits to DNA Casework

The interpretation of DNA mixtures continues to be a pervasive topic in the field of forensic DNA analysis. With the long awaited publication of the NIST MIX05 MIX13 study, and an increasing number of DNA laboratories turning to probabilistic genotyping, it’s worth stopping for a moment to consider just how the... MORE
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Stephen Turner, Ph.D. Joins Signature Science, LLC as Senior Informatics S&T Advisor

Dr. Turner will apply his informatics and genomics expertise to the development of leading-edge forensic genomics solutions for national security, defense, and law enforcement challenges, such as cold case investigations.  AUSTIN, TEXAS — Feb. 5, 2019 - Signature Science, LLC is pleased to announce that Dr. Stephen Turner has joined... MORE
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SigSci’s Austin TX DNA Forensics Laboratory Participated in an Interlab Study of STRmix™ Probabilistic Genotyping...

Title: STRmix™ collaborative exercise on DNA mixture interpretation Summary: An intra- and inter-laboratory study using the probabilistic genotyping (PG) software STRmix™ is reported. Two complex mixtures from the PROVEDIt set, analysed on an Applied Biosystems™ 3500 Series Genetic Analyzer, were selected. 174 participants responded. For Sample 1 (low template, in the... MORE
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SigSci Awarded $2.3M IARPA Contract to Develop Novel Forensic Identification Methods that Sequence Protein Instead...

AUSTIN, TEXAS — August 08, 2018 — The Intelligence Advanced Research Projects Activity (IARPA) awarded Signature Science, LLC, a $2.3M contract for the development of the Proteo-ID method. Proteo-ID aims to accurately identify people via protein sequencing from human skin cell samples. The Proteo-ID methodology will significantly expand human forensic... MORE
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SigSci Awarded Contract from IARPA to Develop New Computational Tools

Austin, Texas – September 21, 2017 – The Intelligence Advanced Research Projects Activity (IARPA) awarded Signature Science, LLC a $2.9M contract for the development of new computational tools to screen DNA sequences to detect biological threats that may manifest from synthetic microbial manipulation. The challenge is to overcome the speed... MORE
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Paper Authored by SigSci Scientists Published in Peer-Reviewed Journal “Analytical Chemistry”

Title: A Systematic Method for the Targeted Discovery of Chemical Attribution Signatures – Application to Isopropyl Bicyclophosphate Production Abstract: Potential attribution signatures for the synthesis of a highly toxic bicyclophosphate, 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide (Isopropyl Bicyclophosphate or IPBCP) were discovered using a trilateral synthetic, analytical, and statistical approach. Initially, five synthetic routes were... MORE