September 29, 2026

Published in “Nature Communications”: Defending Synthetic DNA Orders Against Intra-order Splitting-based Obfuscation

Abstract: Biosecurity screening of synthetic DNA orders is a key defense against malicious actors and careless enthusiasts producing dangerous pathogens or toxins. It is important to evaluate biosecurity screening tools for potential vulnerabilities and to work responsibly with providers to ensure that vulnerabilities can be patched before being publicly disclosed.... MORE
September 28, 2026

Horizon Newsletter – September 2026

Expert witness testimony can make the difference in a case, and learning to root testimony in the science, the processes, and the data is pivotal to ensuring DNA evidence presented stands up to the pressures of a courtroom setting. 2026 marks the third consecutive year that our testimony workshop has... MORE
September 1, 2026

Published in “Computers & Chemical Engineering”: Space Biomanufacturing of Lactic acid: Conceptual Design and Techno-Economic...

Abstract: Space biomanufacturing supports long-term missions by generating products on-site and thereby reducing costly resupply. Because the deployment cost is dominated by the mass of transported components and resources, the total mass becomes a key design driver. The total system mass is thus a critical factor that dictates its design;... MORE
May 12, 2026

Horizon Newsletter – May 2026

Signature Science has validated a SNP mixture deconvolution workflow for two-person DNA mixtures, a breakthrough enabling new leads from evidence previously unusable. When a sample contains DNA from two contributors, our process separates the mixture to produce a single-source SNP profile for the major contributor, making it suitable for forensic... MORE
April 28, 2026

Published in “FSI Genetics”: Advancing forensic SNP typing: Insights from an interlaboratory study of the...

Abstract: This study evaluated the ability to produce FORensic Capture Enrichment (FORCE) genotypes using amplicon-based and capture-based enrichment assays. The FORCE panel is a standardized set of single nucleotide polymorphism (SNP) markers developed for forensic applications. Twelve DNA samples were prepared and distributed to the laboratories for testing: five control... MORE
March 16, 2026

Signature Science Interviewed for RAND AI Safety Paper

March 16, 2026 • Last year, Signature Science AI Biosafety Lead Dr. Danielle LeSassier was interviewed as part of a multi-institutional study led by RAND into the state of Human Uplift Studies for informing AI Safety. As providers in this space, SigSci designs approaches to empirically test the biological and chemical... MORE
February 27, 2026

Horizon Newsletter – February 2026

We’re gearing up for another ASCLD Symposium and are excited to be part of 2026’s packed agenda! We’re hosting two plenary talks and one deep dive session. Scroll for a preview of SigSci Forensics on the agenda. Dates & Times TBA! View full Horizon Newsletter and sign up for future... MORE
February 10, 2026

New Preprint: Predicting Neutron Radiation Exposure Characteristics from an in vitro Human Skin Model Using RNA-seq

Abstract: Accurate assessment of low-dose neutron radiation exposure remains a central challenge in biodosimetry, particularly for applications requiring non-invasive sample types such as skin. Here, we characterized the transcriptional response of a three-dimensional in vitro human skin model (EpiDermFT) to neutron irradiation at doses up to 0.75 Gy, measured from pre-exposure through... MORE

Dr. Ben H. Thacker Joins Signature Science’s Managers Committee

Thacker serves as Chief Operating Officer of Southwest Research Institute. AUSTIN, TX - February 10, 2026 - Signature Science, LLC is pleased to announce the addition of Dr. Ben H. Thacker, P.E. to its Managers Committee following his appointment as Southwest Research Institute's Chief Operating Officer. Dr. Thacker brings nearly... MORE