Latest Research

Internal Validation of the ForenSeq Kintelligence Kit for Application to Forensic Genetic Genealogy

Abstract Forensic Genetic Genealogy (FGG) requires high density single nucleotide polymorphism (SNP) profiles to infer distant relationships. The ForenSeq Kintelligence kit is a recently developed method targeting approximately 10,000 SNPs that were selected to be compatible with genetic genealogy databases, while avoiding medically relevant SNPs. The targeted PCR method is... MORE
Sequencing and classifying harmful algal bloom samples

Paper Published in “Data in Brief”: Environmental DNA sequencing dataset from Lake Erie algal blooms...

Abstract Here we describe a publicly available environmental DNA (eDNA) sequence dataset, consisting of samples collected from a National Oceanic and Atmospheric Administration (NOAA) Great Lakes Environmental Research Laboratory (GLERL) on Lake Erie. We sequenced samples drawn from before, during, and after a 2019 Microcystis harmful algal bloom (HAB) using 3rd generation... MORE

Paper Published in “SPIE. Digital Library”: Development of a High-Energy X-ray Diffractometer for Quality Control...

Abstract The Transportation Security Laboratory of the Department of Homeland Security Science and Technology Directorate is tasked with establishing quality control metrics for assessing the performance of x-ray imaging technologies used by airport security. In conformity with that mission, a high-energy x-ray diffraction apparatus was constructed to characterize the xray... MORE
Relationship inference Paper Published

Paper Published in “Forensic Genomics”: Relationship Inference with Low-Coverage Whole Genome Sequencing on Forensic Samples

Abstract Background: Single nucleotide polymorphism (SNP)-based kinship analysis is now a cornerstone of modern forensic genomics. Imputation can be used to augment genome-wide SNP data from low-coverage whole-genome sequencing (LCWGS). The impact of imputation after LCWGS on genotyping error and its subsequent impact on kinship analysis are unknown. Methods: We assessed the... MORE

Paper Published in “Science Advances”: COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation,...

Abstract The coronavirus disease 2019 (COVID-19) Exposure Assessment Tool (CEAT) allows users to compare respiratory relative risk to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for various scenarios, providing understanding of how combinations of protective measures affect risk. CEAT incorporates mechanistic, stochastic, and epidemiological factors including the (i) emission rate... MORE

SigSci Scientists Co-Author Study Published in “Frontiers in Genetics”

Abstract Technological advances in sequencing and single nucleotide polymorphism (SNP) genotyping microarray technology have facilitated advances in forensic analysis beyond short tandem repeat (STR) profiling, enabling the identification of unknown DNA samples and distant relationships. Forensic genetic genealogy (FGG) has facilitated the identification of distant relatives of both unidentified remains... MORE

Signature Science Co-Authors Study Published in “BMC: Genome Biology”

Abstract The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge. To address this need we developed SeqScreen, which accurately characterizes short nucleotide sequences using taxonomic and functional labels and a customized set of curated... MORE
orange bursts

Minireview Published in ASM Infection and Immunity: Categorizing Sequences of Concern by Function To Better...

Abstract To identify sequences with a role in microbial pathogenesis, we assessed the adequacy of their annotation by existing controlled vocabularies and sequence databases. Our goal was to regularize descriptions of microbial pathogenesis for improved integration with bioinformatic applications. Here, we review the challenges of annotating sequences for pathogenic activity.... MORE