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Horizon Newsletter – April 2025

Accredited FGG Services to Better Serve You! Signature Science’s Advanced Genomics Laboratory has been accredited by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs). As part of the accreditation process, our laboratory successfully passed ANAB’s assessment with zero non-conformances and demonstrated full compliance with the FBI’s Quality Assurance Standards for Forensic Testing Laboratories. View the full Horizon newsletter and sign up for future updates here. MORE

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PLANES: Plausibility Analysis of Epidemiological Signals – Published in “PLoS One”

Abstract:Methods for reviewing epidemiological signals are necessary to building and maintaining data-driven public health capabilities. We have developed a novel approach for assessing the plausibility of infectious disease forecasts and surveillance data. The PLANES (PLausibility ANalysis of Epidemiological Signals) methodology is designed to … MORE

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DNA Retrieved from Spent Shell Casing Presented as Evidence in Washington, DC Homicide Case

March 31, 2025 – Spent Shell Casing evidence submitted to Signature Science for DNA extraction and analysis was presented in a Washington, DC homicide trial this week. The analyst who processed the evidence delivered expert witness testimony. From the article: “The … MORE

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New and Revised Gene Ontology Biological Process Terms Describe Multiorganism Interactions Critical for Understanding Microbial Pathogenesis and Sequences of Concern

Abstract: Background There is a new framework from the United States government for screening synthetic nucleic acids. Beginning in October of 2026, it calls for the screening of sequences 50 nucleotides or greater in length that are known to contribute to pathogenicity … MORE

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Signature Science selected for GSA Unrestricted OASIS+ Research and Development Contract

AUSTIN, TEXAS – March 04, 2025 – Signature Science, LLC is a recipient of an award under the General Services Administration (GSA) Unrestricted OASIS+ (One Acquisition Solution for Integrated Services Plus) contract vehicle. The company has a prime award in the Research and Development domain.OASIS+ is a “Best-in-Class” (BIC) government-wide, multiple-award, Indefinite Delivery, Indefinite Quantity (IDIQ) contract designed to address the procurement needs of federal agencies across eight service domains. With a base period of five years and an optional five-year extension, the contract provides agencies with flexibility, scalability, and efficiency for their services-based solutions.“We’re thrilled to be selected for … MORE

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Signature Science Achieves ISO/IEC 17025:2017 Accreditation for Massively Parallel Sequencing (MPS)

Achievement builds on Company’s forensic science laboratory’s accreditation scope and expands its accredited offerings into the Forensic Genetic Genealogy space. AUSTIN, TEXAS – February 25, 2025 – Signature Science’s Advanced Genomics Laboratory has been issued accreditation by ANAB, the ANSI National … MORE

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Horizon Newsletter – February 2025

Laboratory Leadership at AAFS Documentary standards play a critical role in ensuring consistency, quality, and credibility in forensic science. Hosted in collaboration with Travis County Medical Examiner’s Office, our Deep-Dive session at AAFS will explore the importance of standards development, how … MORE

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Published in “FSI Genetics”: MixDeR: A SNP mixture deconvolution workflow for forensic genetic genealogy

Abstract: The generation of forensic DNA profiles consisting of single nucleotide polymorphisms (SNPs) is now being facilitated by wider adoption of next-generation sequencing (NGS) methods in casework laboratories. At the same time, and in part because of this advance, there … MORE

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Report Details Signature Science Contributions to LMI Group’s Efforts to Authenticate  “Elimar” (1889)

January 29, 2025 • A press release issued by LMI Group International, Inc. detailed the conclusion of multi-year, interdisciplinary investigation to authenticate a painting and attribute it to the artist, Vincent van Gogh. The investigation combined traditional authentication and innovative scientific methods. During … MORE

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An Investigation of Downstream Processing Methods for Challenging Skeletal Samples

Abstract: While skeletal remains are known for their resilience and often serve as the final source of information for unidentified human remains (UHRs), the traditional downstream processing of these samples is challenging due to their low template nature, DNA degradation, and … MORE

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HORIZON Newsletter – November 2024

Sample mixtures and the ability to deconvolute SNP profiles present a challenge for investigations using FGG. These mixtures are common in forensics, however, database search algorithms utilized for FGG only accommodate single-source SNP profiles. To address this gap, NBFAC and … MORE

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