Signature Science has validated a SNP mixture deconvolution workflow for two-person DNA mixtures, a breakthrough enabling new leads from evidence previously unusable. When a sample contains DNA from two contributors, our process separates the mixture to produce a single-source SNP profile for the major contributor, making it suitable for forensic investigative genetic genealogy (FIGG) analysis. The advent of this technology means that more evidence types can be considered for FIGG. Critically, depending on the mixture ratio, our workflow can be used with or without a reference sample. Unsure if your sample is a good fit? Leave it to us! We will evaluate … MORE
Abstract: This study evaluated the ability to produce FORensic Capture Enrichment (FORCE) genotypes using amplicon-based and capture-based enrichment assays. The FORCE panel is a standardized set of single nucleotide polymorphism (SNP) markers developed for forensic applications. Twelve DNA samples were … MORE
Signature Science Interviewed for RAND AI Safety Paper
March 16, 2026 • Last year, Signature Science AI Biosafety Lead Dr. Danielle LeSassier was interviewed as part of a multi-institutional study led by RAND into the state of Human Uplift Studies for informing AI Safety. As providers in this space, … MORE
Horizon Newsletter – February 2026
We’re gearing up for another ASCLD Symposium and are excited to be part of 2026’s packed agenda! We’re hosting two plenary talks and one deep dive session. Scroll for a preview of SigSci Forensics on the agenda. Dates & Times TBA! View … MORE
Abstract: Accurate assessment of low-dose neutron radiation exposure remains a central challenge in biodosimetry, particularly for applications requiring non-invasive sample types such as skin. Here, we characterized the transcriptional response of a three-dimensional in vitro human skin model (EpiDermFT) to neutron irradiation at doses up to 0.75 Gy, measured from pre-exposure through a 14-day post-exposure period. RNA sequencing revealed greater than 800 significantly altered genes, including upregulation of FOS, FOSB, CDKN1A, MDM2, and GADD45A, and downregulation of NRG1, H3C11, and CENPX. Gene ontology enrichment indicated activation of DNA damage checkpoint signaling, cell cycle arrest, and stress-response pathways, alongside suppression of nucleosome assembly and DNA replication processes. Machine … MORE
Dr. Ben H. Thacker Joins Signature Science’s Managers Committee
Thacker serves as Chief Operating Officer of Southwest Research Institute. AUSTIN, TX – February 10, 2026 – Signature Science, LLC is pleased to announce the addition of Dr. Ben H. Thacker, P.E. to its Managers Committee following his appointment as Southwest … MORE
Abstract: Introduction: Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious intent to cause … MORE
Horizon Newsletter – November 2025
Collaboration Leads to a Breakthrough in a Case That’s Close to Home After over 30 years, breakthroughs in forensic science have led investigators to identify a person of interest in the 1991 murders of four young Austin-area girls; Eliza Thomas, Amy … MORE
Signature Science Membership on ARPA-H BREATHE Program Team Announced
October 22, 2025 • A press release issued by The University of Virginia Biocomplexity Institute announced that the Advanced Research Projects Agency for Health (ARPA-H) has awarded a contract for up to $40 million through its Bioaerosol Risk Assessment interVention Engineering … MORE
Company will apply biological and chemical threat expertise to evaluate AI models for risk of malicious misuse. AUSTIN, TEXAS – October 21, 2025 – Signature Science, LLC, has been selected for the National Institute of Standards and Technology (NIST) Center for … MORE
Authorized Statement on the Yogurt Shop Murders Investigation
October 07, 2025 – After over 30 years, breakthroughs in forensic science have led investigators to identify a person of interest in the 1991 murders of four young Austin-area girls; Eliza Thomas, Amy Ayers, and sisters Jennifer Harbison and Sarah … MORE